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KMID : 0043320070300050556
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Archives of Pharmacal Research
2007 Volume.30 No. 5 p.556 ~ p.560
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Cytotoxic Germacranolide Sesquiterpene Lactones from Carpesium triste var. manshuricum
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Kim Mi-Ran
Hwang Bang-Yeon
Jeong Eun-Sook
Lee Yong-Moon
Yoo Hwan-Soo
Jung Yeun-Bok
Hong Jin-Tae
Moon Dong-Cheul
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Abstract
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Four known germacranolide sesquiterpene lactones, 2α,5-epoxy-5,10-dihydroxy-6α-angeloyloxy-9β-isobutyloxy-germacran-8α,12-olide (1), 2α,5-epoxy-5,10-dihydroxy-6α,9β-diangeloyloxy-germacran-8α,12-olide (2, divaricin B), 2α,5-epoxy-5,10-dihydroxy-6α-angeloyloxy-9β-(2-methylbutyloxy)-germacran-8α,12-olide (3) and 2α,5-epoxy-5,10-dihydroxy-6α-angeloyloxy-9β-(3-methylbutyloxy)-germacran-8α,12-olide (4), were isolated from the chloroform-soluble fraction of the whole plants of Carpesium triste var. manshuricum. Their chemical structures were determined using spectroscopic methods, including 2D-NMR. All the isolates showed significant cytotoxicities (ED50 value: 4.3-16.8 μM) against five human tumor cell lines; A549, SKOV-3, SK-MEL-2, XF498 and HCT15.
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KEYWORD
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Carpesium triste var. manshuricum, Compositae, Sesquiterpene lactone, Germacrane, Cytotoxic activity
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